Amination Under Ball Milling

An operationally simple mechanochemical method for the pd catalysed buchwaldhartwig amination of arylhalides with secondary amines has been developed using a pd peppsi catalyst systemhe system is demonstrated on 30 substrates and applied in the context of a target synthesisurthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution.

Henan Mining Heavy Machinery Co., Ltd.

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